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KMID : 1146920190490010009
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 1 p.9 ~ p.15
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Recent advances in intra-articular drug delivery systems to extend drug retention in joint
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Ho Myoung-Jin
Kim Sung-Rae
Choi Young-Wook
Kang Myung-Joo
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Abstract
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Intra-articular (IA) administration of therapeutic agents has been employed to selectively deliver active compounds at their site of action for the treatment of chronic joint diseases such as osteoarthritis, rheumatoid arthritis, and joint pain. Direct IA delivery of active compounds to local tissues occasionally provides improved therapeutic outcomes with reduced dose, while minimizing systemic exposure and undesirable adverse effects. However, many small drugs (
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KEYWORD
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Intra-articular drug delivery, Nanoparticles, Microparticles, Hydrogels, Prolonged release, Joints
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